Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/53621
Title: MICROARRAY-ASSISTED DISCOVERY OF PROTEIN-PROTEIN INTERACTION INHIBITORS AND ENZYME PROBES
Authors: NA ZHENKUN
Keywords: Microarray, High-throughput, screening tools, protein-protein interaction, Inhibitor, probe,
Issue Date: 16-Jan-2014
Source: NA ZHENKUN (2014-01-16). MICROARRAY-ASSISTED DISCOVERY OF PROTEIN-PROTEIN INTERACTION INHIBITORS AND ENZYME PROBES. ScholarBank@NUS Repository.
Abstract: The microarray platform can be used in high-capacity, high-throughput screening tool for discoverying the small molecule inhibitor for the protein-protein interaction. In chapter 2, by using a small molecular microarray as a high-throughput screening platform, we have successfully discovered two potent inhibitors of cathepsin L. In chapter 3, a fragment-based small molecule library for BRCA1 BRCT domains has been developed and discovered the first cell-permeable small molecule.
URI: http://scholarbank.nus.edu.sg/handle/10635/53621
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