Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/53223
Title: The inhibition of 3βHSD activity in porcine granulosa cells by 4-MA, a potent 5α-reductase inhibitor
Authors: Chan, W.K. 
Fong, C.Y.
Tiong, H.H.
Tan, C.H. 
Issue Date: 1987
Source: Chan, W.K.,Fong, C.Y.,Tiong, H.H.,Tan, C.H. (1987). The inhibition of 3βHSD activity in porcine granulosa cells by 4-MA, a potent 5α-reductase inhibitor. Biochemical and Biophysical Research Communications 144 (1) : 166-171. ScholarBank@NUS Repository.
Abstract: Addition of 17β-N,N-diethylcarbamoyl-4-methyl-4-aza-5α-androstan-3- one, a potent 5α-reductase inhibitor, to granulosa cell cultures inhibited the FSH-stimulated progesterone synthesis during both the initial 48 h induction period and the subsequent 6h test period in a dose-dependent fashion. Besides being a more potent inhibitor of FSH-stimulated progesterone synthesis than testosterone, 4-MA also synergised with the androgen to inhibit progesterone synthesis. These results indicate that 4-MA has a direct inhibitory action on 3β-HSD.
Source Title: Biochemical and Biophysical Research Communications
URI: http://scholarbank.nus.edu.sg/handle/10635/53223
ISSN: 0006291X
Appears in Collections:Staff Publications

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