The inhibition of 3βHSD activity in porcine granulosa cells by 4-MA, a potent 5α-reductase inhibitor

Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/53223

Title:	The inhibition of 3βHSD activity in porcine granulosa cells by 4-MA, a potent 5α-reductase inhibitor
Authors:	Chan, W.K. Fong, C.Y. Tiong, H.H. Tan, C.H.
Issue Date:	1987
Citation:	Chan, W.K., Fong, C.Y., Tiong, H.H., Tan, C.H. (1987). The inhibition of 3βHSD activity in porcine granulosa cells by 4-MA, a potent 5α-reductase inhibitor. Biochemical and Biophysical Research Communications 144 (1) : 166-171. ScholarBank@NUS Repository.
Abstract:	Addition of 17β-N,N-diethylcarbamoyl-4-methyl-4-aza-5α-androstan-3- one, a potent 5α-reductase inhibitor, to granulosa cell cultures inhibited the FSH-stimulated progesterone synthesis during both the initial 48 h induction period and the subsequent 6h test period in a dose-dependent fashion. Besides being a more potent inhibitor of FSH-stimulated progesterone synthesis than testosterone, 4-MA also synergised with the androgen to inhibit progesterone synthesis. These results indicate that 4-MA has a direct inhibitory action on 3β-HSD.
Source Title:	Biochemical and Biophysical Research Communications
URI:	http://scholarbank.nus.edu.sg/handle/10635/53223
ISSN:	0006291X
Appears in Collections:	Staff Publications

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