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|Title:||The inhibition of 3βHSD activity in porcine granulosa cells by 4-MA, a potent 5α-reductase inhibitor|
|Authors:||Chan, W.K. |
|Source:||Chan, W.K.,Fong, C.Y.,Tiong, H.H.,Tan, C.H. (1987). The inhibition of 3βHSD activity in porcine granulosa cells by 4-MA, a potent 5α-reductase inhibitor. Biochemical and Biophysical Research Communications 144 (1) : 166-171. ScholarBank@NUS Repository.|
|Abstract:||Addition of 17β-N,N-diethylcarbamoyl-4-methyl-4-aza-5α-androstan-3- one, a potent 5α-reductase inhibitor, to granulosa cell cultures inhibited the FSH-stimulated progesterone synthesis during both the initial 48 h induction period and the subsequent 6h test period in a dose-dependent fashion. Besides being a more potent inhibitor of FSH-stimulated progesterone synthesis than testosterone, 4-MA also synergised with the androgen to inhibit progesterone synthesis. These results indicate that 4-MA has a direct inhibitory action on 3β-HSD.|
|Source Title:||Biochemical and Biophysical Research Communications|
|Appears in Collections:||Staff Publications|
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