Screening of traditional medicines for their inhibitory activity against HIV-1 protease

Please use this identifier to cite or link to this item: https://doi.org/10.1002/(SICI)1099-1573(199605)10:3<207

Title:	Screening of traditional medicines for their inhibitory activity against HIV-1 protease
Authors:	Xu, H.-X. Wan, M. Loh, B.-N. Kon, O.-L. Chow, P.-W. Sim, K.-Y.
Keywords:	Aqueous extracts Fluorogenic assay Inhibition of HIV-1 protease Traditional medicines
Issue Date:	May-1996
Citation:	Xu, H.-X.,Wan, M.,Loh, B.-N.,Kon, O.-L.,Chow, P.-W.,Sim, K.-Y. (1996-05). Screening of traditional medicines for their inhibitory activity against HIV-1 protease. Phytotherapy Research 10 (3) : 207-210. ScholarBank@NUS Repository. https://doi.org/10.1002/(SICI)1099-1573(199605)10:3<207
Abstract:	Aqueous extracts of 75 different traditional medicines, currently used for the treatment of various human diseases in China, Japan and Indonesia, were screened for possible inhibitory activity against HIV-1 protease using fluorogenic assay. Forty extracts exhibited inhibitory activity at a concentration of 250 μg/mL, and 18 of them inhibited HIV-1 protease activity by more than 70%. Among the extracts examined, Belamcanda chinensis, Magnolia fargesii, Paeonia suffruticosa, Phellodendron amurense and Terminalia chebula were also effective at a concentration of 25 μg/mL in the fluorogenic assay.
Source Title:	Phytotherapy Research
URI:	http://scholarbank.nus.edu.sg/handle/10635/53153
ISSN:	0951418X
DOI:	10.1002/(SICI)1099-1573(199605)10:3<207
Appears in Collections:	Staff Publications

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