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|Title:||Screening of traditional medicines for their inhibitory activity against HIV-1 protease|
|Authors:||Xu, H.-X. |
Inhibition of HIV-1 protease
|Source:||Xu, H.-X.,Wan, M.,Loh, B.-N.,Kon, O.-L.,Chow, P.-W.,Sim, K.-Y. (1996-05). Screening of traditional medicines for their inhibitory activity against HIV-1 protease. Phytotherapy Research 10 (3) : 207-210. ScholarBank@NUS Repository. https://doi.org/10.1002/(SICI)1099-1573(199605)10:3<207|
|Abstract:||Aqueous extracts of 75 different traditional medicines, currently used for the treatment of various human diseases in China, Japan and Indonesia, were screened for possible inhibitory activity against HIV-1 protease using fluorogenic assay. Forty extracts exhibited inhibitory activity at a concentration of 250 μg/mL, and 18 of them inhibited HIV-1 protease activity by more than 70%. Among the extracts examined, Belamcanda chinensis, Magnolia fargesii, Paeonia suffruticosa, Phellodendron amurense and Terminalia chebula were also effective at a concentration of 25 μg/mL in the fluorogenic assay.|
|Source Title:||Phytotherapy Research|
|Appears in Collections:||Staff Publications|
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