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|Title:||Platinum(iv) prodrugs entrapped within multiwalled carbon nanotubes: Selective release by chemical reduction and hydrophobicity reversal|
|Authors:||Li, J. |
|Source:||Li, J., Yap, S.Q., Chin, C.F., Tian, Q., Yoong, S.L., Pastorin, G., Ang, W.H. (2012-06). Platinum(iv) prodrugs entrapped within multiwalled carbon nanotubes: Selective release by chemical reduction and hydrophobicity reversal. Chemical Science 3 (6) : 2083-2087. ScholarBank@NUS Repository. https://doi.org/10.1039/c2sc01086k|
|Abstract:||Platinum-based anticancer drugs constitute some of most effective chemotherapeutic regimes, but they are limited by high toxicities and severe side-effects arising from premature aquation and non-specific interactions. Macromolecular delivery agents can be used to shield platinum drugs from adventitious binding and as a platform to attach targeting groups, as a strategy to mitigate some of these limitations. An approach was conceived to utilise carbon nanotubes as a protective shell for stable platinum(iv) prodrugs entrapped within its inner cavities. An inert and strongly hydrophobic platinum(iv) complex was designed for entrapment within multiwalled carbon nanotubes via hydrophobic-hydrophobic interactions. Upon chemical reduction, the drug was converted to its cytotoxic and hydrophilic form and released from the carrier, via a drastic reversal in hydrophobicity, for DNA-binding. This simple method of hydrophobic entrapment and controlled release by chemical reduction and hydrophobicity reversal, exploiting the Pt(iv) scaffold as a prodrug, could form the basis of other delivery strategies for targeted delivery of platinum drugs into cancer cells. © 2012 The Royal Society of Chemistry.|
|Source Title:||Chemical Science|
|Appears in Collections:||Staff Publications|
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