Please use this identifier to cite or link to this item: https://doi.org/10.1039/c2sc01086k
Title: Platinum(iv) prodrugs entrapped within multiwalled carbon nanotubes: Selective release by chemical reduction and hydrophobicity reversal
Authors: Li, J. 
Yap, S.Q.
Chin, C.F.
Tian, Q. 
Yoong, S.L.
Pastorin, G. 
Ang, W.H. 
Issue Date: Jun-2012
Source: Li, J., Yap, S.Q., Chin, C.F., Tian, Q., Yoong, S.L., Pastorin, G., Ang, W.H. (2012-06). Platinum(iv) prodrugs entrapped within multiwalled carbon nanotubes: Selective release by chemical reduction and hydrophobicity reversal. Chemical Science 3 (6) : 2083-2087. ScholarBank@NUS Repository. https://doi.org/10.1039/c2sc01086k
Abstract: Platinum-based anticancer drugs constitute some of most effective chemotherapeutic regimes, but they are limited by high toxicities and severe side-effects arising from premature aquation and non-specific interactions. Macromolecular delivery agents can be used to shield platinum drugs from adventitious binding and as a platform to attach targeting groups, as a strategy to mitigate some of these limitations. An approach was conceived to utilise carbon nanotubes as a protective shell for stable platinum(iv) prodrugs entrapped within its inner cavities. An inert and strongly hydrophobic platinum(iv) complex was designed for entrapment within multiwalled carbon nanotubes via hydrophobic-hydrophobic interactions. Upon chemical reduction, the drug was converted to its cytotoxic and hydrophilic form and released from the carrier, via a drastic reversal in hydrophobicity, for DNA-binding. This simple method of hydrophobic entrapment and controlled release by chemical reduction and hydrophobicity reversal, exploiting the Pt(iv) scaffold as a prodrug, could form the basis of other delivery strategies for targeted delivery of platinum drugs into cancer cells. © 2012 The Royal Society of Chemistry.
Source Title: Chemical Science
URI: http://scholarbank.nus.edu.sg/handle/10635/53093
ISSN: 20416520
DOI: 10.1039/c2sc01086k
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