Please use this identifier to cite or link to this item: https://doi.org/10.1038/ncb1598
Title: p73 supports cellular growth through c-Jun-dependent AP-1 transactivation
Authors: Vikhanskaya, F.
Toh, W.H.
Dulloo, I.
Wu, Q.
Boominathan, L.
Ng, H.H. 
Vousden, K.H.
Sabapathy, K. 
Issue Date: Jun-2007
Source: Vikhanskaya, F.,Toh, W.H.,Dulloo, I.,Wu, Q.,Boominathan, L.,Ng, H.H.,Vousden, K.H.,Sabapathy, K. (2007-06). p73 supports cellular growth through c-Jun-dependent AP-1 transactivation. Nature Cell Biology 9 (6) : 698-706. ScholarBank@NUS Repository. https://doi.org/10.1038/ncb1598
Abstract: The cause or consequence of overexpression of p73 (refs 1, 2), the structural and functional homologue of the tumour-suppressor gene product p53 (refs 3, 4), in human cancers is poorly understood. Here, we report a role for p73 in supporting cellular growth through the upregulation of AP-1 transcriptional activity. p73 suppresses growth when overexpressed alone, but synergises with the proto-oncogene c-Jun to promote cellular survival. Conversely, silencing of p73 expression compromises cellular proliferation. Molecular analysis revealed that expression of the AP-1 target-gene product cyclinD1 (ref. 5) is reduced concomitant with p73, but not p53, silencing. Moreover, cyclinD1 was induced by p73 expression in a c-Jun-dependent manner, and was required for p73-mediated cell survival. Furthermore, c-Jun-dependent AP-1 transcriptional activity was augmented by p73 and, consistently, induction of endogenous AP-1 target genes was compromised in the absence of p73. Chromatin immunoprecipitation and electrophoretic mobility shift analysis indicated that p73 enhanced the binding of phosphorylated c-Jun and Fra-1, another AP-1 family member, to AP-1 consensus DNA sequences, by regulating c-Jun phosphorylation and Fra-1 expression. Collectively, our data demonstrates a novel and unexpected role of p73 in augmenting AP-1 transcriptional activity through which it supports cellular growth.
Source Title: Nature Cell Biology
URI: http://scholarbank.nus.edu.sg/handle/10635/53080
ISSN: 14657392
DOI: 10.1038/ncb1598
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