Please use this identifier to cite or link to this item: https://doi.org/10.1177/0095399703258682
Title: Use of Bone Marrow Stromal Cells for Tendon Graft-to-Rone Healing: Histological and Immunohistochemical Studies in a Rabbit Model
Authors: Ouyang, H.W. 
Goh, J.C.H. 
Lee, E.H.
Keywords: Bone marrow stromal cell
Cell therapy
Fibrocartilagenous insertion
Tendon-to-bone healing
Issue Date: Mar-2004
Source: Ouyang, H.W.,Goh, J.C.H.,Lee, E.H. (2004-03). Use of Bone Marrow Stromal Cells for Tendon Graft-to-Rone Healing: Histological and Immunohistochemical Studies in a Rabbit Model. American Journal of Sports Medicine 32 (2) : 321-327. ScholarBank@NUS Repository. https://doi.org/10.1177/0095399703258682
Abstract: Background: Despite increasing attention on the issue of tendon-to-bone integration, there has been no animal study on the use of cell therapy for promoting the insertion healing of tendon to bone. Purpose: To determine the efficacy of using a large number of bone marrow stromal cells (bMSCs) to enhance tendon-to-bone healing. Study Design: Controlled laboratory study. Methods: The hallucis longus tendons were translated into 2.5-mm diameter calcaneal bone tunnels in a New Zealand white rabbit model. The bone tunnels were treated with or without bMSCs. Three specimens from each group were harvested at 2, 4, and 6 weeks postoperatively and evaluated by conventional histological and immunohistochemical methods. Results: At 4 weeks, the specimens with bMSCs exhibited more perpendicular collagen fiber formation and increased proliferation of cartilage-like cells, which was indicated by positive collagen type-II immuno-staining of the tendon-bone interface. In contrast, the specimens without bMSCs demonstrated progressive maturation and reorganization of fibrous tissue aligned along the load axis. Conclusion: Introduction of a large number of bone marrow stromal cells to the bone tunnel have shown to improve the insertion healing of tendon to bone in a rabbit model through formation of fibrocartilagenous attachment at early time points.
Source Title: American Journal of Sports Medicine
URI: http://scholarbank.nus.edu.sg/handle/10635/52562
ISSN: 03635465
DOI: 10.1177/0095399703258682
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