Please use this identifier to cite or link to this item:
|Title:||Use of Bone Marrow Stromal Cells for Tendon Graft-to-Rone Healing: Histological and Immunohistochemical Studies in a Rabbit Model|
|Authors:||Ouyang, H.W. |
|Keywords:||Bone marrow stromal cell|
|Citation:||Ouyang, H.W., Goh, J.C.H., Lee, E.H. (2004-03). Use of Bone Marrow Stromal Cells for Tendon Graft-to-Rone Healing: Histological and Immunohistochemical Studies in a Rabbit Model. American Journal of Sports Medicine 32 (2) : 321-327. ScholarBank@NUS Repository. https://doi.org/10.1177/0095399703258682|
|Abstract:||Background: Despite increasing attention on the issue of tendon-to-bone integration, there has been no animal study on the use of cell therapy for promoting the insertion healing of tendon to bone. Purpose: To determine the efficacy of using a large number of bone marrow stromal cells (bMSCs) to enhance tendon-to-bone healing. Study Design: Controlled laboratory study. Methods: The hallucis longus tendons were translated into 2.5-mm diameter calcaneal bone tunnels in a New Zealand white rabbit model. The bone tunnels were treated with or without bMSCs. Three specimens from each group were harvested at 2, 4, and 6 weeks postoperatively and evaluated by conventional histological and immunohistochemical methods. Results: At 4 weeks, the specimens with bMSCs exhibited more perpendicular collagen fiber formation and increased proliferation of cartilage-like cells, which was indicated by positive collagen type-II immuno-staining of the tendon-bone interface. In contrast, the specimens without bMSCs demonstrated progressive maturation and reorganization of fibrous tissue aligned along the load axis. Conclusion: Introduction of a large number of bone marrow stromal cells to the bone tunnel have shown to improve the insertion healing of tendon to bone in a rabbit model through formation of fibrocartilagenous attachment at early time points.|
|Source Title:||American Journal of Sports Medicine|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Feb 19, 2019
WEB OF SCIENCETM
checked on Feb 19, 2019
checked on Nov 10, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.