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|Title:||Improving hydrophilicity, mechanical properties and biocompatibility of poly[(R)-3-hydroxybutyrate-co-(R)-3-hydroxyvalerate] through blending with poly[(R)-3-hydroxybutyrate]-alt-poly(ethylene oxide)|
|Source:||Li, X., Liu, K.L., Wang, M., Wong, S.Y., Tjiu, W.C., He, C.B., Goh, S.H., Li, J. (2009-07). Improving hydrophilicity, mechanical properties and biocompatibility of poly[(R)-3-hydroxybutyrate-co-(R)-3-hydroxyvalerate] through blending with poly[(R)-3-hydroxybutyrate]-alt-poly(ethylene oxide). Acta Biomaterialia 5 (6) : 2002-2012. ScholarBank@NUS Repository. https://doi.org/10.1016/j.actbio.2009.01.035|
|Abstract:||Natural source poly[(R)-3-hydroxybutyrate-co-(R)-3-hydroxyvalerate] (PHBV) with a low hydroxyvalerate (HV) content (∼8 wt.%) was modified by blending it with poly[(R)-3-hydroxybutyrate]-alt-poly(ethylene oxide) (HE) alternating block copolymer. We hypothesized that the adjoining PHB segments could improve the miscibility of the poly(ethylene oxide) segments of HE with the PHBV matrix and therefore improve the physical properties of the PHBV/HE blends. A differential scanning calorimetry study revealed the improved miscibility of PEO segments of HE characterized by the interference of the crystallization of PHBV. The decrease in water contact angle and the increase in equilibrium water uptake of the PHBV/HE blends indicated that both the surface and bulk hydrophilicity of PHBV could be improved through blending HE. The mechanical properties of the hydrated PHBV/HE blends were assessed by measuring their tensile strength. In contrast to the hydrated natural source PHBV, which failed in a brittle manner, the hydrated PHBV/HE blends were ductile. Their strain at break increased with increasing HE content, reaching a maximum of 394% at an HE content of 15 wt.%. The excellent integrity of the PHBV/HE blends in water is attributed to the strong affinity between the PHB segments of HE and the PHBV matrix. Platelet adhesion on the film surface of the PHBV/HE blends was investigated in vitro to evaluate their blood compatibility. The results demonstrated that the PHBV/HE blends effectively resisted the adhesion of platelets due to the anchored PEO segments from HE on the film surface. © 2009 Acta Materialia Inc.|
|Source Title:||Acta Biomaterialia|
|Appears in Collections:||Staff Publications|
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