Please use this identifier to cite or link to this item:
|Title:||Exploration of ionic modification in dual-lifer hollow fiber membranes for long-term high-performance protein separation|
|Authors:||Li, Y. |
|Keywords:||Dual-layer hollow fiber membranes|
|Source:||Li, Y., Soh, S.C., Chung, T.-S., Chan, S.Y. (2009-02). Exploration of ionic modification in dual-lifer hollow fiber membranes for long-term high-performance protein separation. AIChE Journal 55 (2) : 321-330. ScholarBank@NUS Repository. https://doi.org/10.1002/aic.11671|
|Abstract:||Two types of ionic modification approaches (i.e., sulfonation and triethylamination) were applied with the aid of dual-layer hollow fiber technology in this work to fine tune the pore size and pore size distribution, introduce the electrostatic interaction, and reduce membrane fouling for long-term high-performance protein separation. A binary protein mixture comprising bovine serum albumin (BSA) and hemoglobin (Hb) was separated in this work. The sulfonated fiber exhibits an improved BSA/Hb separation factor at pH = 6.8 compared with as-spun fibers hut at the expense of BSA sieving coefficient. On the other hand, the triethylaminated fiber reveals the best and most durable separation performance at pH = 4.8. Its BSA/Hb separation factor is maintained above 80 for 4 days and maximum BSA sieving coefficient reaches 33%. Therefore, this study documents that an intelligent combination of both size-exclusion and electrostatic interaction can synergistically enhance protein separation performance in both purity and concentration. © 2008 American Institute of Chemical Engineers.|
|Source Title:||AIChE Journal|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Feb 28, 2018
WEB OF SCIENCETM
checked on Feb 21, 2018
checked on Feb 27, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.