Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jconrel.2009.12.030
Title: Controlled drug release from biodegradable thermoresponsive physical hydrogel nanofibers
Authors: Loh, X.J.
Peh, P.
Liao, S. 
Sng, C.
Li, J. 
Keywords: Block copolymers
Controlled release
Human dermal fibroblast cells
Hydrogel
Nanofiber
Thermosensitive
Tissue engineering
Issue Date: Apr-2010
Source: Loh, X.J., Peh, P., Liao, S., Sng, C., Li, J. (2010-04). Controlled drug release from biodegradable thermoresponsive physical hydrogel nanofibers. Journal of Controlled Release 143 (2) : 175-182. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jconrel.2009.12.030
Abstract: Hydrogel nanofiber mats based on thermoresponsive multiblock poly(ester urethane)s comprising poly(ethylene glycol) (PEG), poly(propylene glycol) (PPG), and poly(ε-caprolactone) (PCL) segments were fabricated by electrospinning. The hydrogel nanofiber mats were more water absorbent under cold conditions and shrunk when exposed to higher temperatures. The rate of protein release could be controlled by changing the temperature of the nanofiber environment. Cell culture studies on the nanofiber mats were carried out using human dermal fibroblasts, and healthy cell morphology was observed. The adherent viable cells were quantified by MTS after rinsing in excess buffer solution. The results showed that these nanofiber scaffolds supported excellent cell adhesion, comparable with the pure PCL nanofibers. The increased hydrophilicity of these hydrogel nanofiber mats led to a more rapid hydrolytic degradation, compared with the pure PCL nanofiber mats. These hydrogel nanofiber scaffolds could potentially be used as thermoresponsive biodegradable supporting structures for skin tissue engineering applications. © 2010 Elsevier B.V.
Source Title: Journal of Controlled Release
URI: http://scholarbank.nus.edu.sg/handle/10635/51362
ISSN: 01683659
DOI: 10.1016/j.jconrel.2009.12.030
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