Please use this identifier to cite or link to this item: https://doi.org/10.1073/pnas.1113079108
Title: Common oxytocin receptor gene (OXTR) polymorphism and social support interact to reduce stress in humans
Authors: Chen, F.S.
Kumsta, R.
Von Dawans, B.
Monakhov, M. 
Ebstein, R.P. 
Heinrichs, M.
Issue Date: 13-Dec-2011
Source: Chen, F.S., Kumsta, R., Von Dawans, B., Monakhov, M., Ebstein, R.P., Heinrichs, M. (2011-12-13). Common oxytocin receptor gene (OXTR) polymorphism and social support interact to reduce stress in humans. Proceedings of the National Academy of Sciences of the United States of America 108 (50) : 19937-19942. ScholarBank@NUS Repository. https://doi.org/10.1073/pnas.1113079108
Abstract: The neuropeptide oxytocin has played an essential role in the regulation of social behavior and attachment throughout mammalian evolution. Because recent studies in humans have shown that oxytocin administration reduces stress responses and increases prosocial behavior, we investigated whether a common single nucleotide polymorphism (rs53576) in the oxytocin receptor gene (OXTR) might interact with stress-protective effects of social support. Salivary cortisol samples and subjective stress ratings were obtained from 194 healthy male participants before, during, and after a standardized psychosocial laboratory stress procedure. Participants were randomly assigned either to prepare alone or to receive social support from their female partner or close female friend while preparing for the stressful task. Differential stress responses between the genotype groups were observed depending on the presence or absence of social support. Only individuals with one or two copies of the G allele of rs53576 showed lower cortisol responses to stress after social support, compared with individuals with the same genotype receiving no social support. These results indicate that genetic variation of the oxytocin system modulates the effectiveness of positive social interaction as a protective buffer against a stressful experience.
Source Title: Proceedings of the National Academy of Sciences of the United States of America
URI: http://scholarbank.nus.edu.sg/handle/10635/49967
ISSN: 00278424
DOI: 10.1073/pnas.1113079108
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