Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0048597
Title: Epigenetic and Genetic Factors Predict Women's Salivary Cortisol following a Threat to the Social Self
Authors: Edelman, S.
Shalev, I.
Uzefovsky, F.
Israel, S.
Knafo, A.
Kremer, I.
Mankuta, D.
Kaitz, M.
Ebstein, R.P. 
Issue Date: 14-Nov-2012
Citation: Edelman, S., Shalev, I., Uzefovsky, F., Israel, S., Knafo, A., Kremer, I., Mankuta, D., Kaitz, M., Ebstein, R.P. (2012-11-14). Epigenetic and Genetic Factors Predict Women's Salivary Cortisol following a Threat to the Social Self. PLoS ONE 7 (11) : -. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0048597
Abstract: Evidence suggests that the reactivity of the Hypothalamus-Pituitary-Adrenal axis (HPAA) is modulated by both genetic and environmental variables. Of special interest are the underlying molecular mechanisms driving gender differences to psychosocial stressors. Epigenetic mechanisms that sculpt the genome are ideal candidates for mediating the effects of signals on the HPAA. In the current study, we analyzed by pyrosequencing, bisulfite-treated buccal DNA from male and female university students who participated in the Trier Social Stress Test (TSST). A linear regression model was used to ascertain the effects of sex, CpG methylation and genes on stress response. Total cortisol output (area under the curve, AUC) was significantly predicted by glucocorticoid receptor (NR3C1) exon 1F methylation (averaged across 39 CpG sites) solely in female subjects. A single CpG site located in the exon 1F noncanonical nerve growth factor-inducible protein A (NGFI-A) transcription factor was a highly significant predictor of AUC in female subjects. Additionally, variations in the estrogen receptor alpha (ESR1) and the serotonin transporter promoter (5-HTTLPR) genes were independent additive predictors of AUC. The full model accounted for half of the variance (50.06%) in total cortisol output. Notably, this is the first demonstration that epigenetic changes at the GR exon 1F correlate with HPAA reactivity. These findings have important implications for understanding the molecular mechanisms underlying gender differences in stress-related disorders and underscore the unique value of modeling both epigenetic and genetic information in conferring vulnerability to stress. © 2012 Edelman et al.
Source Title: PLoS ONE
URI: http://scholarbank.nus.edu.sg/handle/10635/49860
ISSN: 19326203
DOI: 10.1371/journal.pone.0048597
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
2012-Epigenetic_and_Genetic_Factors_Predict-published.PDF390.62 kBAdobe PDF

OPEN

PublishedView/Download

SCOPUSTM   
Citations

34
checked on Jul 17, 2018

WEB OF SCIENCETM
Citations

29
checked on Jul 17, 2018

Page view(s)

73
checked on Jun 30, 2018

Download(s)

4
checked on Jun 30, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.