Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/49442
Title: ISOLATION, QUANTIFICATION OF PIGMENTS AND MONACOLIN K FROM RED YEAST RICE AND THEIR ASSOCIATED BIOACTIVITIES IN CULTURED HUMAN CARCINOMA CELLS
Authors: WEI YING
Keywords: red yeast rice, pigments, monacolin K, isolation, bioactivities, carcinoma cells
Issue Date: 16-Aug-2013
Source: WEI YING (2013-08-16). ISOLATION, QUANTIFICATION OF PIGMENTS AND MONACOLIN K FROM RED YEAST RICE AND THEIR ASSOCIATED BIOACTIVITIES IN CULTURED HUMAN CARCINOMA CELLS. ScholarBank@NUS Repository.
Abstract: Red yeast rice has traditionally been used as a natural food colorant, food preservative and traditional Chinese medicine. It has been reported its pleiotropic effects including: 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, antifungal, antioxidant, anti-inflammatory, anti-hypertensive, anti-cancer proliferative, suppression adipogenesis, antimicrobial, simulating osteoblast proliferation, immunosuppressive, and anti-diabetic activities. These effects are related to two bioactive groups: monacolins and pigments. This study has developed optimal extraction, purification and quantification methods for yellow pigments (ankaflavin, monascin, monaphilone A and monaphilone B); red pigments (rubropunctamine and monascorubramine) from red yeast rice and investigated their associated bioactivities in three human carcinoma cells. The overall results indicated that monacolin K and pigments inhibited proliferation of carcinoma cells through induction of apoptosis by cytochrome c release via multi-pathways activation. These pigments and monacolin K may be new precursor compounds in the development of new natural anti-cancer reagent.
URI: http://scholarbank.nus.edu.sg/handle/10635/49442
Appears in Collections:Ph.D Theses (Open)

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