Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/49083
Title: STAT5 REGULATES HELPER T CELL LINEAGE COMMITMENT AND AUTOIMMUNITY
Authors: SHENG WANQIANG
Keywords: Helper T cell, lineage commitment, STAT5, GM-CSF, EAE, colitis
Issue Date: 7-Aug-2013
Source: SHENG WANQIANG (2013-08-07). STAT5 REGULATES HELPER T CELL LINEAGE COMMITMENT AND AUTOIMMUNITY. ScholarBank@NUS Repository.
Abstract: CD4+ T cells play crucial roles in host defense against various pathogens by orchestrating adaptive immune responses. Upon T-cell receptor activation by cognate antigen, naive CD4+ T cells are committed to differentiate into at least five major lineages: Th1, Th2, Th17, iTeg and Tfh cells, which are orchestrated by cytokine milieus signaling through Signal Transducer and Activa?tor of Transcription (STAT) family proteins. In my project, I have studied the regulatory roles of STAT5 in CD4+ T cell lineage commitment and two types of autoimmune diseases: experimental autoimmune encephalomyelitis and T cell-transfer colitis.
URI: http://scholarbank.nus.edu.sg/handle/10635/49083
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