Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/48464
Title: NOVEL POLARIZATION SENSITIVE CONTRAST AGENTS FOR OPTICAL COHERENCE TOMOGRAPHY
Authors: MEHTA KALPESH BADRESHKUMAR
Keywords: OCT, Plasmonics, Polarization, Darkfield, Contrast agents, Molecular imaging
Issue Date: 18-Dec-2012
Source: MEHTA KALPESH BADRESHKUMAR (2012-12-18). NOVEL POLARIZATION SENSITIVE CONTRAST AGENTS FOR OPTICAL COHERENCE TOMOGRAPHY. ScholarBank@NUS Repository.
Abstract: Optical coherence tomography (OCT) is a widely used structural imaging method. However, it has limited use molecular imaging due to the lack of an effective contrast mechanism. Gold nanoparticles have been widely used as molecular probes for optical microcopy based on Surface Plasmon Resonance (SPR). Unfortunately, the SPR enhanced backscattering from nanoparticles is still relatively weak compared with the background signal from microscopic structures in biological tissues when imaged with OCT. Consequently, it is extremely challenging to perform OCT imaging of conventional nanoparticles in thick tissues with sensitivity comparable to that of fluorescence imaging. We have discovered and demonstrated a novel approach towards remarkable contrast enhancement, which is achieved by the use of a circular-polarization optical coherence microscopy system and 3-dimensional chiral nanostructures as contrast agents. By detecting the circular intensity differential depolarization (CIDD), we successfully acquired high quality images of single chiral nanoparticles underneath a 1-mm-thick tissue-mimic phantom.
URI: http://scholarbank.nus.edu.sg/handle/10635/48464
Appears in Collections:Ph.D Theses (Open)

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