Please use this identifier to cite or link to this item: https://doi.org/10.1359/JBMR.040714
Title: Strategies for directing the differentiation of stem cells into the osteogenic lineage in vitro
Authors: Boon, C.H. 
Cao, T. 
Stanton, L.W.
Robson, P.
Olsen, B.
Keywords: Differentiation
In vitro
Osteogenesis
Stem cells
Transplantation
Issue Date: 2004
Source: Boon, C.H., Cao, T., Stanton, L.W., Robson, P., Olsen, B. (2004). Strategies for directing the differentiation of stem cells into the osteogenic lineage in vitro. Journal of Bone and Mineral Research 19 (9) : 1379-1394. ScholarBank@NUS Repository. https://doi.org/10.1359/JBMR.040714
Abstract: A major area in regenerative medicine is the application of stem cells in bone reconstruction and bone tissue engineering. This will require well-defined and efficient protocols for directing the differentiation of stem cells into the osteogenic lineage, followed by their selective purification and proliferation in vitro. The development of such protocols would reduce the likelihood of spontaneous differentiation of stem cells into divergent lineages on transplantation, as well as reduce the risk of teratoma formation in the case of embryonic stem cells. Additionally, such protocols could provide useful in vitro models for studying osteogenesis and bone development, and facilitate the genetic manipulation of stem cells for therapeutic applications. The development of pharmokinetic and cytotoxicity/genotoxicity screening tests for bone-related biomaterials and drugs could also use protocols developed for the osteogenic differentiation of stem cells. This review critically examines the various strategies that could be used to direct the differentiation of stem cells into the osteogenic lineage in vitro. © 2004 American Society for Bone and Mineral Research.
Source Title: Journal of Bone and Mineral Research
URI: http://scholarbank.nus.edu.sg/handle/10635/47127
ISSN: 08840431
DOI: 10.1359/JBMR.040714
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