Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/43751
Title: SOLID PHASE SYNTHESIS OF FLUORESCENT DYE LIBRARIES AND THEIR APPLICATIONS IN BIO-IMAGING
Authors: RAJ KUMAR DAS
Keywords: Bio-imaging, Coumarin, fluorescent probe, BODIPY, Rhodol, Cyanine
Issue Date: 14-Jan-2013
Source: RAJ KUMAR DAS (2013-01-14). SOLID PHASE SYNTHESIS OF FLUORESCENT DYE LIBRARIES AND THEIR APPLICATIONS IN BIO-IMAGING. ScholarBank@NUS Repository.
Abstract: The elegant solid phase chemistry is devised for providing a robust synthetic route generating a large number of fluorescent libraries in a short span and synthesis of fluorescent libraries covering wide emission color spectra from Vis to NIR has been carried out. CyR is cyanine based ultra-photostable, NIR dye library and its derivatives have been applied to discover in vivo macrophage imaging probe (CyRCA-341) and in vitro SERS based multiplexing SERS probe (CyRLA-572) for differentiated mouse embryonic stem cells. From BDR library, (BODIPY dyes), B-cell selective probes CDg6 has been discovered and applied it separate B cell from mouse splenocytes. From RDR library, (rhodol dyes) and using cell based screening, cell cycle probe (RDR-567) was discovered that specifically stains to the mitosis compared to the inter phase during the cell division. Finally, coumarin based large stokes shift (150 nm) COR library has been synthesized hoping to develop further imaging probe.
URI: http://scholarbank.nus.edu.sg/handle/10635/43751
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
DasRK.pdf9.56 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

162
checked on Dec 11, 2017

Download(s)

39
checked on Dec 11, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.