Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/39608
Title: An accurate and efficient algorithm for Peptide and ptm identification by tandem mass spectrometry.
Authors: Ning, K.
Ng, H.K.
Leong, H.W. 
Issue Date: 2007
Source: Ning, K.,Ng, H.K.,Leong, H.W. (2007). An accurate and efficient algorithm for Peptide and ptm identification by tandem mass spectrometry.. Genome informatics. International Conference on Genome Informatics 19 : 119-130. ScholarBank@NUS Repository.
Abstract: Peptide identification by tandem mass spectrometry (MS/MS) is one of the most important problems in proteomics. Recent advances in high throughput MS/MS experiments result in huge amount of spectra. Unfortunately, identification of these spectra is relatively slow, and the accuracies of current algorithms are not high with the presence of noises and post-translational modifications (PTMs). In this paper, we strive to achieve high accuracy and efficiency for peptide identification problem, with special concern on identification of peptides with PTMs. This paper expands our previous work on PepSOM with the introduction of two accurate modified scoring functions: Slambda for peptide identification and Slambda* for identification of peptides with PTMs. Experiments showed that our algorithm is both fast and accurate for peptide identification. Experiments on spectra with simulated and real PTMs confirmed that our algorithm is accurate for identifying PTMs.
Source Title: Genome informatics. International Conference on Genome Informatics
URI: http://scholarbank.nus.edu.sg/handle/10635/39608
ISSN: 09199454
Appears in Collections:Staff Publications

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