Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/39309
Title: Finding functional promoter motifs by computational methods: A word of caution
Authors: Chowdhary, R.
Wong, L. 
Bajic, V.B.
Keywords: Motifs
Promoter
Transcription Factor Binding Sites (TFBSs)
Transcription Start Sites (TSSs)
Translation Initiation Sites (TIS)
Issue Date: 2006
Source: Chowdhary, R.,Wong, L.,Bajic, V.B. (2006). Finding functional promoter motifs by computational methods: A word of caution. International Journal of Bioinformatics Research and Applications 2 (3) : 282-288. ScholarBank@NUS Repository.
Abstract: The standard practice in the analysis of promoters is to select promoter regions of convenient length. This may lead to false results when searching for Transcription Factor Binding Sites (TFBSs), since the sequences may contain coding segments. In such cases, motif detection may single out motifs from the coding regions. The mapping of TFBSs to promoters may result in a misleading picture of 'promoter' content. We illustrate these issues using the example of histones H2A and H2B and show how such analysis could be misleading if care is not exercised to eliminate coding regions from the presumed promoter sequences. Copyright © 2006 Inderscience Enterprises Ltd.
Source Title: International Journal of Bioinformatics Research and Applications
URI: http://scholarbank.nus.edu.sg/handle/10635/39309
ISSN: 17445458
Appears in Collections:Staff Publications

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