Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/38817
Title: TOWARDS A CONSISTENT CHRONOLOGY TO EXPLAIN THE EVOLUTION OF THE RIBOSOME
Authors: ZHANG BO
Keywords: Ribosome, Evolution, Design Structure Matrix, Hydrothermal Vent, Maya
Issue Date: 24-Aug-2012
Source: ZHANG BO (2012-08-24). TOWARDS A CONSISTENT CHRONOLOGY TO EXPLAIN THE EVOLUTION OF THE RIBOSOME. ScholarBank@NUS Repository.
Abstract: The ribosome is a molecular witness to the origin of life as it comprises the conserved mechanism for the translation of nucleic acid gene sequences into proteins in all living creatures. The large subunit is reducible to a core peptidyl-transferase structure, which is proposed as its ancestral form. A model of hierarchical addition of E. coli 23S rRNA modular inserts was recently proposed to explain ribosomal evolution from this core structure, however large numbers of alternative chronologies are possible. Our refinement of this model using the Design Structure Matrix (DSM) provides a surprisingly detailed picture of the transitional events. Similar methods can be adapted to the chronology model of ribosome small subunit of E. coli, with which, the evolutionary story of the integrated E. coli ribosome can be presented as a 3D animation using Autodesk Maya. It would enlarge our knowledge about the RNA world approximately 3.8 billion years ago.
URI: http://scholarbank.nus.edu.sg/handle/10635/38817
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
ZhangBo_video.mov11.99 MBVideo Quicktime

OPEN

None Preview online
View/Download
ZhangB.pdf27.26 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

143
checked on Dec 2, 2017

Download(s)

60
checked on Dec 2, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.