Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/38663
Title: THE ROLE OF STEM CELL FACTOR SALL4 IN HEPATOCELLULAR CARCINOMA
Authors: YONG KOL JIA
Keywords: SALL4, heptocallular carcinoma, targeted therapy, prognostic factor, progenitor-like
Issue Date: 14-Jan-2013
Source: YONG KOL JIA (2013-01-14). THE ROLE OF STEM CELL FACTOR SALL4 IN HEPATOCELLULAR CARCINOMA. ScholarBank@NUS Repository.
Abstract: Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide. Treatment of HCC remains abysmal; discovery of novel pathways implicated in hepatocarcinogenesis is needed for more effective therapeutics. SALL4 is a stem cell factor that regulates ESC self-renewal properties. It is also an emerging oncogene. The aim of this thesis is to study the potential roles of SALL4 as a molecular biomarker for HCC and its functional roles in promoting hepatocarcinogenesis. In this study, we report a novel oncofetal protein in HCC, SALL4, which allows identification of a progenitor HCC subset with worse prognosis, and offers a potential treatment target. Importantly, our multivariate analysis confirmed that SALL4 is an independent prognostic factor for HCC. Gain- and loss-of-function studies confirmed that SALL4 is critical for hepatocarcinogenesis. Importantly, we demonstrated that a peptide can block the oncogenic function of SALL4 in HCC by modulating the PTEN/AKT pathway.
URI: http://scholarbank.nus.edu.sg/handle/10635/38663
Appears in Collections:Ph.D Theses (Open)

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