Please use this identifier to cite or link to this item:
|Title:||Signalling of GPI-anchored CD157 via focal adhesion kinase in MCA102 fibroblasts|
Focal adhesion kinase
|Source:||Liang, F.,Chang, C.F. (2001). Signalling of GPI-anchored CD157 via focal adhesion kinase in MCA102 fibroblasts. FEBS Letters 506 (3) : 207-210. ScholarBank@NUS Repository. https://doi.org/10.1016/S0014-5793(01)02912-X|
|Abstract:||CD157, a glycosylphosphatidylinositol-anchored protein, has previously been shown to mediate tyrosine phosphorylation of a 130 kDa protein (p130) in several cell lines. In this study, we have identified the p130 protein to be focal adhesion kinase (FAK or pp125FAK). FAK undergoes phosphorylation at Tyr-397 and Tyr-861 in intact MCA102 cells stably transfected with CD157 (MCA/CD157). MCA/CD157 cells, which displayed a rounded and compact cell morphology, exhibited a dispersed distribution, in contrast to a more closely associated and elongated spindle cell shape in the vector-transfected cells. MCA/CD157 cells proliferated at a rate 20-25% slower than the control cells. Our results demonstrate, for the first time, that FAK is a downstream signalling molecule of CD157. © 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.|
|Source Title:||FEBS Letters|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Dec 13, 2017
WEB OF SCIENCETM
checked on Nov 1, 2017
checked on Dec 9, 2017
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.