Please use this identifier to cite or link to this item:
|Title:||Lophozozymyus pictor toxin: A fluorescent structural isomer of palytoxin|
|Source:||Lau, C.O., Tan, C.H., Khoo, H.E., Yuen, R., Lewis, R.J., Corpuz, G.P., Bignami, G.S. (1995). Lophozozymyus pictor toxin: A fluorescent structural isomer of palytoxin. Toxicon 33 (10) : 1373-1377. ScholarBank@NUS Repository. https://doi.org/10.1016/0041-0101(95)00075-W|
|Abstract:||Purified Lophozozymus pictor toxin (LPTX) shares many properties similar to palytoxin (PTX). LPTX and palytoxin isolated from Palythoa caribaeorum (C-PTX) have similar mol. wts of approx. 2680 on ionspray mass spectrometry (MS). In addition, antibodies against PTX could recognize and bind LPTX. Mixed mode high-performance liquid chromatography (HPLC) of LPTX, C-PTX and H-PTX (isolated from Palythoa tuberculosa) showed a major PTX component common to all three with the characteristic PTX-like UV spectrum at a retention time (R(t)) of 17 min. However, LPTX exhibits fluorescence but PTX of equivalent toxicity does not LPTX showed a unique peak at R(t) of approx. 22 min on mixed mode HPLC. In addition, LPTX and C-PTX showed different ion fragmentation patterns on MS/MS. These results suggest that LPTX and the palytoxins are structural isomers, containing at least one difference which gives rise to fluorescence in LPTX.|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Feb 15, 2018
WEB OF SCIENCETM
checked on Feb 5, 2018
checked on Feb 20, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.