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|Title:||Lophozozymyus pictor toxin: A fluorescent structural isomer of palytoxin|
|Citation:||Lau, C.O., Tan, C.H., Khoo, H.E., Yuen, R., Lewis, R.J., Corpuz, G.P., Bignami, G.S. (1995). Lophozozymyus pictor toxin: A fluorescent structural isomer of palytoxin. Toxicon 33 (10) : 1373-1377. ScholarBank@NUS Repository. https://doi.org/10.1016/0041-0101(95)00075-W|
|Abstract:||Purified Lophozozymus pictor toxin (LPTX) shares many properties similar to palytoxin (PTX). LPTX and palytoxin isolated from Palythoa caribaeorum (C-PTX) have similar mol. wts of approx. 2680 on ionspray mass spectrometry (MS). In addition, antibodies against PTX could recognize and bind LPTX. Mixed mode high-performance liquid chromatography (HPLC) of LPTX, C-PTX and H-PTX (isolated from Palythoa tuberculosa) showed a major PTX component common to all three with the characteristic PTX-like UV spectrum at a retention time (R(t)) of 17 min. However, LPTX exhibits fluorescence but PTX of equivalent toxicity does not LPTX showed a unique peak at R(t) of approx. 22 min on mixed mode HPLC. In addition, LPTX and C-PTX showed different ion fragmentation patterns on MS/MS. These results suggest that LPTX and the palytoxins are structural isomers, containing at least one difference which gives rise to fluorescence in LPTX.|
|Appears in Collections:||Staff Publications|
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