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|Title:||Plasma levels of 13,14-dihydro-15-keto PGE2after vaginal application of a new PGE2film|
|Citation:||Prasad, R.N.V., Roy, A.C., Kottegoda, S.R. (1985). Plasma levels of 13,14-dihydro-15-keto PGE2after vaginal application of a new PGE2film. Prostaglandins 29 (2) : 269-272. ScholarBank@NUS Repository. https://doi.org/10.1016/0090-6980(85)90207-2|
|Abstract:||To determine the release and absorption profile of prostaglandin E2 from a new vaginal film formulation containing 850 μg PGE2, serial plasma levels of 13,14-dihydro-15-keto PGE2 were measured by radioimmunoassay in pregnant women between 16 and 18 weeks gestation. A control group, using placebo vaginal film was included in the study. There was a somewhat uniform increase in the plasma levels of the PGE2 metabolite, reaching peak levels between 4 and 6 hours after application of the film. The findings suggest that this drug formulation could be used clinically when slow constant release of the prostaglandin is required over a period of hours such as in pre-induction cervical ripening of term pregnancy.|
|Appears in Collections:||Staff Publications|
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