Effect of Norplant®-2 rods on haemostatic function

Abstract

A longitudinal study on one-hundred Singaporean women using Norplant®-2 rod implant for contraception and their effects on the haemostatic function was carried out. There was a decrease in vitamin K-dependent Factors II, VII and a tendency towards lowered fibrinolytic activity after prolonged use of Norplant®-2 rods. The results indicate that the Norplant®-2 rod implant system does not contribute towards hypercoagulable state but increased platelets and accelerated platelet aggregation observed will require further study to ascertain whether there is a concomitant increase in platelet activation.