Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/36349
Title: The Role of downstream of kinase (DOK)-3 in Toll-like receptor signalling
Authors: KIM SOO YEON
Keywords: DOK3, TLR3, TLR4, RIG-I, IFN-beta, TNF-alpha
Issue Date: 10-Aug-2012
Source: KIM SOO YEON (2012-08-10). The Role of downstream of kinase (DOK)-3 in Toll-like receptor signalling. ScholarBank@NUS Repository.
Abstract: Toll-like receptors (TLR) are germ-line encoded pattern recognition receptors (PRR) that detect infectious agents specific signatures present on pathogens collectively referred to as pathogen associated molecular pattern (PAMP). LPS, an endotoxin and poly(I:C) which is a synthetic oligonucleotide that mimics double-stranded RNA (dsRNA) binds to TLR-4 and 3 respectively and activates the TIR-containing adaptor inducing interferon beta (TRIF)-dependent signal transduction cascade. Because Downstream of kinase (Dok)-1 and Dok2 were known to regulate TLR, we hypothesized that Dok3 may be involved in TLR regulation as well. We hence investigated if Dok3 is involved in TLR signalling in macrophages.
URI: http://scholarbank.nus.edu.sg/handle/10635/36349
Appears in Collections:Ph.D Theses (Open)

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