Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/35603
Title: CONTROL OF CELL DIVISION AND DIFFERENTIATION IN THE ARABIDOPSIS ROOT - STUDIES ON THE AUXIN RESISTAN 3 (AXR3) GENE
Authors: WANG YANBIN
Keywords: Auxin Resistant 3, PIN, Cell division, Cell differentiation, Stem cell niche, Non-cell-autonomous
Issue Date: 2-Aug-2012
Source: WANG YANBIN (2012-08-02). CONTROL OF CELL DIVISION AND DIFFERENTIATION IN THE ARABIDOPSIS ROOT - STUDIES ON THE AUXIN RESISTAN 3 (AXR3) GENE. ScholarBank@NUS Repository.
Abstract: Tight and balanced control of cell division and cell differentiation is crucial for plant development. In Arabidopsis, auxin signaling mediated by its repressors AUX/IAA proteins, plays a key role in mediating root development and growth. However, it is still not well understood how AUX/IAA proteins coordinates cell division and cell differentiation in the Arabidopsis root. Here, we show that gain-of-function mutations in the AXR3 gene, encoding the AUX/IAA protein IAA17, result in defective stem cell specification and formative cell divisions in the root ground tissue layer. Genetics interaction studies suggest that AXR3 acts in parallel with SCR, SHR and PLT genes, mediating patterning of the Arabidopsis root stem cell niche. Intriguingly, AXR3 expresses only in differentiated root cap cells and differentiating or differentiated cells proximal to the root meristem, indicating a non-cell-autonomous mode of regulation. Indeed we found that AXR3 could regulate auxin distribution and accumulation in the stem cell niche by repressing the activities of several PIN auxin efflux facilitators in the AXR3-expressing cells. Together, our results reveal, for the first time, that auxin signaling in the differentiating or differentiated cells could direct cell specification and division in the stem cell niche.
URI: http://scholarbank.nus.edu.sg/handle/10635/35603
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
PhD thesis-Wang Yanbin.pdf5.52 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

186
checked on Dec 18, 2017

Download(s)

95
checked on Dec 18, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.