Please use this identifier to cite or link to this item:
Title: Structural and Epitope Characterization of Major Allergens from Dust Mite, BLO T 21 and DER F 7
Keywords: dust mite, allergen, structural studies, IgE epitope mapping, biophysical studies
Issue Date: 18-Nov-2011
Citation: TAN KANG WEI (2011-11-18). Structural and Epitope Characterization of Major Allergens from Dust Mite, BLO T 21 and DER F 7. ScholarBank@NUS Repository.
Abstract: House dust mites are recognized as a major cause of allergic diseases worldwide. Here, we present the 3D structures and immuno-characterization of Blo t 21 and Der f 7, two major allergens from house dust mites. The NMR structure of Blo t 21 resembles that of its paralogue, Blo t 5. The immunological studies showed that Blo t 21 could have a unique conformational epitope, and a different linear epitope compared to that of Blo t 5, thus explaining their limited cross-reactivity. The crystal structure of Der f 7 is very similar to its homologue, Der p 7. Residues L48 and F50 should be the IgE epitopes of Der f 7 but residue D159 is unlikely to be responsible for its cross-reactivity with Der p 7 as reported previously. Both allergens show unique immunological properties and therefore should be considered for the future development of immunotherapy.
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Thesis_Tan Kang Wei.pdf4.66 MBAdobe PDF



Page view(s)

checked on Feb 9, 2019


checked on Feb 9, 2019

Google ScholarTM


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.