Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/34703
Title: COMPUTATIONAL BIOENGINEERING OF THE GASTROINTESTINAL TRACT
Authors: POH YONG CHENG
Keywords: Multi-scale computational modelling, Ion channels, Smooth muscle cell, Sodium channelopathy, Motility disorder, Electromechanics
Issue Date: 14-May-2012
Source: POH YONG CHENG (2012-05-14). COMPUTATIONAL BIOENGINEERING OF THE GASTROINTESTINAL TRACT. ScholarBank@NUS Repository.
Abstract: The pathogenic potential of sodium channel related mutations of R76C and G298S in causing gastrointestinal (GI) motility disorders was computationally investigated from an electrophysiological perspective, through integrative multi-scale modelling. Models describing the wild-type and mutation-altered sodium channels, in key motility cell-types of interstitial cell of Cajal (ICC) and smooth muscle cell (SMC), were developed for investigation at higher spatial scales. A single cell model of the small intestinal SMC was developed, and together with well-established single cell gastric models of ICC and SMC, they were used to investigate effects of the mutations on cellular electrophysiology. To further study the mutations, a gastric tissue model that incorporates multiple ICC and SMC through an extended bidomain approach, with proper electrical entrainment and propagation, was created. The R76C mutation presented a greater potential than the G298S mutation in altering multi-scale electrical behaviour. An electrical disruption may change smooth muscle electromechanics and cause dysmotility.
URI: http://scholarbank.nus.edu.sg/handle/10635/34703
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
PohYC.pdf9.54 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

210
checked on Dec 11, 2017

Download(s)

32
checked on Dec 11, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.