Bioinspired Aromatic Foldamers and Their Potential Applications

Abstract

Synthetic chemists are often interested in how biomolecules assemble and interact with one another non-covalently. From the initial inspirations from these natural biomacromolecules, many functional mimics resulting from supramolcular architecture had been synthesized and had realized several applications in various diverse fields. Using the foldamer chemistry approach, this thesis aims to design and synthesize a new class of pyridine-based backbone-ridigified aromatic foldamers (a) that mimic aquaporin structurally and functionally with potential applications in the field of water purification and desalination, (b) that serve as amine and ammonium receptors that may find important uses in environment and industrial monitoring for the rapid detection and classification of amines and ammonium ions, and (c) that allows the chiral crystallization to take place without the use of chiral auxiliary or external stimuli.