Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0014-5793(00)01593-3
Title: Purification, structure determination and synthesis of covalitoxin-II, a short insect-specific neurotoxic peptide from the venom of the Coremiocnemis validus (Singapore tarantula)
Authors: Balaji, R.A.
Gopalakrishnakone, P. 
Bay, B.-H. 
Sasaki, T.
Sato, K.
Kini, R.M. 
Keywords: Conus toxin
Cystine motif
Reversible neurotoxin
Spider
Spider venom
Issue Date: 2000
Source: Balaji, R.A., Gopalakrishnakone, P., Bay, B.-H., Sasaki, T., Sato, K., Kini, R.M. (2000). Purification, structure determination and synthesis of covalitoxin-II, a short insect-specific neurotoxic peptide from the venom of the Coremiocnemis validus (Singapore tarantula). FEBS Letters 474 (2-3) : 208-212. ScholarBank@NUS Repository. https://doi.org/10.1016/S0014-5793(00)01593-3
Abstract: Spider venoms contain toxins that specifically immobilize and kill insects. We report the purification and characterization of a new insect-specific toxin named covalitoxin-II (Cvtx-II; mass, 3406.24±0.64), from Coremiocnemis validus (Singapore tarantula) venom. The complete 31 amino acid sequence of Cvtx-II has been determined and it shows less than 40% identity with spider toxins. However, Cvtx-II has conserved cystine motif analogous to other spider and ω-conotoxins. Cvtx-II was chemically synthesized and identified with the native Cvtx-II. Synthetic Cvtx-II induced insect-specific non-lethal excitatory activity when injected into crickets, but not in cockroaches and mice. Copyright (C) 2000 Federation of European Biochemical Societies.
Source Title: FEBS Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/33923
ISSN: 00145793
DOI: 10.1016/S0014-5793(00)01593-3
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