Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0304-3940(00)01306-9
Title: Ultrastructure and function of the amoeboid microglial cells in the periventricular white matter in postnatal rat brain following a hypoxic exposure
Authors: Kaur, C. 
You, Y.
Keywords: Ameboid microglial cells
Horseradish peroxidase
Hypoxia
Periventricular white matter
Phagocytic activity
Postnatal rat brain
Issue Date: 2000
Source: Kaur, C., You, Y. (2000). Ultrastructure and function of the amoeboid microglial cells in the periventricular white matter in postnatal rat brain following a hypoxic exposure. Neuroscience Letters 290 (1) : 17-20. ScholarBank@NUS Repository. https://doi.org/10.1016/S0304-3940(00)01306-9
Abstract: The ameboid microglial cells (AMC), located in the periventricular white matter, were examined ultrastucturally in neonatal rats following a hypoxic exposure. For 10 min to 1 day, following the hypoxic exposure, a large number of glial cells with nuclear chromatin condensation, undergoing degeneration, were observed in the white matter. Such cells were often being phagocytosed by the AMC. At 3-7 days after the hypoxic exposure, the cytoplasm of many AMC contained a number of phagosomes whereas at 14-28 days a large amount of lipid accumulation was observed in them. AMC were labeled intensely with horseradish peroxidase (HRP) administered intraperitoneally following the hypoxic exposure. The phagocytosis of degenerating cells by the AMC and uptake of HRP by them indicates that these cells efficiently remove the degenerating cells/debris from the neonatal white matter following hypoxia in an attempt to protect it from any harmful substances that may be secreted by the degenerating cells or from serum derived substances that may enter the brain through blood circulation. Copyright (C) 2000 Elsevier Science Ireland Ltd.
Source Title: Neuroscience Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/33753
ISSN: 03043940
DOI: 10.1016/S0304-3940(00)01306-9
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