Please use this identifier to cite or link to this item: https://doi.org/10.1016/0306-4522(94)90581-9
Title: Up-regulation of surface antigens on epiplexus cells in postnatal rats following intraperitoneal injections of lipopolysaccharide
Authors: Lu, J.
Kaur, C. 
Ling, E.-A. 
Issue Date: 1994
Source: Lu, J., Kaur, C., Ling, E.-A. (1994). Up-regulation of surface antigens on epiplexus cells in postnatal rats following intraperitoneal injections of lipopolysaccharide. Neuroscience 63 (4) : 1169-1178. ScholarBank@NUS Repository. https://doi.org/10.1016/0306-4522(94)90581-9
Abstract: Epiplexus cells in postnatal rats exhibited a remarkable up-regulation of major histocompatibility complex class I and II antigen expression after intraperitoneal administration of bacterial lipopolysaccharide; other surface antigens, i.e. complement type 3 receptors and leukocyte common antigens, were also vigorously elevated when compared with those of the corresponding control rats. The immunostaining of epiplexus cells with OX-42, OX-18 and OX-1 for the detection of complement type 3 receptors, major histocompatibility class I and leukocyte common antigens, respectively, was noticeably enhanced with a drastic increase in their numbers. The most significant finding was the upsurge of OX-6-positive epiplexus cells exhibiting major histocompatibility class II antigens, especially in rats receiving two intraperitoneal injections of lipopolysaccharide and killed at the age of 14 days. Immunoelectron microscopy confirmed the above findings and added the fact that the immunoreactive site was confined to the plasma membrane. An interesting feature was the occurrence of OX-6-positive macrophage-like cells in transit across the choroid epithelium. It is concluded from this study that the upsurge of immunopositive epiplexus cells after lipopolysaccharide injections was partly attributed to the infiltration of stromal macrophages which migrated across the epithelium. The up-regulation of major histocompatibility complex class I and II antigen expression on epiplexus cells by lipopolysaccharide would enable them to carry out self-recognizing and antigen-presenting function in the ventricular system.
Source Title: Neuroscience
URI: http://scholarbank.nus.edu.sg/handle/10635/33537
ISSN: 03064522
DOI: 10.1016/0306-4522(94)90581-9
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

12
checked on Dec 7, 2017

WEB OF SCIENCETM
Citations

14
checked on Nov 22, 2017

Page view(s)

95
checked on Dec 10, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.