Please use this identifier to cite or link to this item:
Title: Potential effects of tetrodotoxin exposure to human glial cells postulated using microarray approach
Authors: Raghavendra, Prasad H.S. 
Srinivasan, K.N. 
Gopalakrishnakone, P. 
Qi, Z.
Keywords: Glial cells
Prostate cancer and microarray
Voltage-gated sodium channels
Issue Date: 2004
Source: Raghavendra, Prasad H.S., Srinivasan, K.N., Gopalakrishnakone, P., Qi, Z. (2004). Potential effects of tetrodotoxin exposure to human glial cells postulated using microarray approach. Toxicon 44 (6) : 597-608. ScholarBank@NUS Repository.
Abstract: Sodium channels play an important role in many neurological disorders and also in prostate cancer. Tetrodotoxin (TTX), a blocker of voltage-gated sodium channels has been chiefly used as a molecular probe for the study and characterization of these channels. The regulation of gene expression in response for the exposure of TTX to glial cells which are reported to be involved in neurodegenerative process is poorly understood. Therefore, the present study aims to develop a repository of genes and map it on a few pivotal neurodegenerative pathways to speculate the effect of TTX. Using Affymetrix GeneChip (HG-U133A), we have selected a subset of 692 differentially expressed genes, several of which are-cullin 4A (CUL4A), ubiquitin carrier protein (E2-EPF), proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional protease 7) (PSMB8), protein tyrosine phosphatase type IVA (PTP4A1), intercellular adhesion molecule 1 (ICAM1), prostaglandin-endoperoxide synthase 2 (PTGS2), and caspase 1 (CASP1). These genes, which facilitate some of the neurodegenerative pathways, such as ubiquitin, proteasome, inflammation and kinases, were identified to be up- or down-regulated for the TTX treatment. Thus, the selected genes were further examined on ubiquitin-proteasome mediated inflammatory responses pathway as ample evidence for the role of glial cell-mediated inflammation in the neurodegenerative process are available. In summary, our result provides a basic understanding of the differentially expressed genes along with one of the possible pathway which may have been modulated by the exposure of TTX. © 2004 Elsevier Ltd. All rights reserved.
Source Title: Toxicon
ISSN: 00410101
DOI: 10.1016/j.toxicon.2004.07.018
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Mar 7, 2018


checked on Jan 30, 2018

Page view(s)

checked on Mar 11, 2018

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.