Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.yexcr.2010.06.007
Title: Silencing of the PP2A catalytic subunit causes HER-2/neu positive breast cancer cells to undergo apoptosis
Authors: Wong, L.L. 
Koay, E.S.C. 
Zhang, D. 
Chang, C.F. 
Keywords: Apoptosis
Caspase 3
HER-2/neu
P38 MAPK
Phosphorylation
PP2A
Issue Date: 2010
Source: Wong, L.L., Koay, E.S.C., Zhang, D., Chang, C.F. (2010). Silencing of the PP2A catalytic subunit causes HER-2/neu positive breast cancer cells to undergo apoptosis. Experimental Cell Research 316 (20) : 3387-3396. ScholarBank@NUS Repository. https://doi.org/10.1016/j.yexcr.2010.06.007
Abstract: Protein phosphatase 2A (PP2A), in its activated form as a phosphatase, is a tumour suppressor. However, when PP2A is phosphorylated at the tyrosine residue (pY307), it loses its phosphatase activity and becomes inactivated. In our previous study, we found a higher expression of pY307-PP2A in HER-2/neu positive breast tumour samples and significantly correlated to tumour progression, and in this context, it could function as a proto-oncogene. The above and subsequent findings led us to postulate that the critical role of PP2A in maintaining the balance between cell survival and cell death may be linked to its phosphorylation status at its Y307 residue. Hence, we further investigated the effects of knocking down the PP2A catalytic subunit which contains the Y307 amino acid residue in two HER-2/neu positive breast cancer cell lines, BT474 and SKBR3. We showed that this causes the silenced HER-2/neu breast cancer cells to undergo apoptosis and furthermore, that such apoptosis is mediated by p38 MAPK-caspase 3/PARP activation. Understanding the role of PP2A in HER2/neu positive cells might thus provide insight into new targets for breast cancer therapy. © 2010 Elsevier Inc. All rights reserved.
Source Title: Experimental Cell Research
URI: http://scholarbank.nus.edu.sg/handle/10635/33199
ISSN: 00144827
10902422
DOI: 10.1016/j.yexcr.2010.06.007
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