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|Title:||Acetylcholinesterase-independent action of diisopropyl-flurophosphate in the rat aorta|
|Source:||Lim, S.L., Sim, M.K., Loke, W.K. (2000). Acetylcholinesterase-independent action of diisopropyl-flurophosphate in the rat aorta. European Journal of Pharmacology 404 (3) : 353-359. ScholarBank@NUS Repository. https://doi.org/10.1016/S0014-2999(00)00629-4|
|Abstract:||Recent studies have shown that many organophosphates can bind competitively and noncompetitively to membrane muscarinic receptors. The present study investigated the responses of the rat aortic rings to diisopropyl-flurophosphate (DFP), an organophsophorus cholinesterase inhibitor, and the possible involvement of muscarinic receptors. DFP caused a concentration-dependent contraction when added cumulatively from 10-8 to 10-4 M. This contraction was inhibited in a noncompetitive manner by high concentrations of atropine (1.5 x 10-6 and 1.8 x 10-6 M) but was unaffected by similar concentrations of selective muscarinic receptor subtype antagonists, pirenzepine, 11-2[2-[(diethylamino)methyl]-1-piperidinyl]acetyl-5,11-dihydro-6 H-rido[2,3-b][1,4]benzodiazepin-6-one (AF-DX116) and 4-Diphenylacetoxy-N-methyl piperidine methiodide (4-DAMP). Phentolamine, an α-adrenoceptor antagonist, was able to inhibit the DFP-induced contraction in a noncompetitive manner at a concentration of 10-7 M. These findings suggested that the DFP-induced contraction in the rat aortic rings was mediated by norepinephrine that was released from sympathetic nerve terminals present in the aortic rings. (C) 2000 Elsevier Science B.V.|
|Source Title:||European Journal of Pharmacology|
|Appears in Collections:||Staff Publications|
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