Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0014-2999(00)00629-4
Title: Acetylcholinesterase-independent action of diisopropyl-flurophosphate in the rat aorta
Authors: Lim, S.L.
Sim, M.K. 
Loke, W.K.
Keywords: (Rat)
Aorta
Diisopropyl-flurophosphate
Norepinephrine
Organophosphate
Phentolami ne
Issue Date: 2000
Source: Lim, S.L., Sim, M.K., Loke, W.K. (2000). Acetylcholinesterase-independent action of diisopropyl-flurophosphate in the rat aorta. European Journal of Pharmacology 404 (3) : 353-359. ScholarBank@NUS Repository. https://doi.org/10.1016/S0014-2999(00)00629-4
Abstract: Recent studies have shown that many organophosphates can bind competitively and noncompetitively to membrane muscarinic receptors. The present study investigated the responses of the rat aortic rings to diisopropyl-flurophosphate (DFP), an organophsophorus cholinesterase inhibitor, and the possible involvement of muscarinic receptors. DFP caused a concentration-dependent contraction when added cumulatively from 10-8 to 10-4 M. This contraction was inhibited in a noncompetitive manner by high concentrations of atropine (1.5 x 10-6 and 1.8 x 10-6 M) but was unaffected by similar concentrations of selective muscarinic receptor subtype antagonists, pirenzepine, 11-2[2-[(diethylamino)methyl]-1-piperidinyl]acetyl-5,11-dihydro-6 H-rido[2,3-b][1,4]benzodiazepin-6-one (AF-DX116) and 4-Diphenylacetoxy-N-methyl piperidine methiodide (4-DAMP). Phentolamine, an α-adrenoceptor antagonist, was able to inhibit the DFP-induced contraction in a noncompetitive manner at a concentration of 10-7 M. These findings suggested that the DFP-induced contraction in the rat aortic rings was mediated by norepinephrine that was released from sympathetic nerve terminals present in the aortic rings. (C) 2000 Elsevier Science B.V.
Source Title: European Journal of Pharmacology
URI: http://scholarbank.nus.edu.sg/handle/10635/32163
ISSN: 00142999
DOI: 10.1016/S0014-2999(00)00629-4
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