Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0014-5793(00)01506-4
Title: Caloric restriction prevents oxidative damage induced by the carcinogen clofibrate in mouse liver
Authors: Qu, B.
Halliwell, B. 
Li, Q.-T. 
Ong, C.N. 
Lee, B.L.
Keywords: 8-Hydroxy-2'-deoxyguanosine
Cancer
Clofibrate
Peroxisome proliferator
Protein carbonyl
Issue Date: 2000
Source: Qu, B., Halliwell, B., Li, Q.-T., Ong, C.N., Lee, B.L. (2000). Caloric restriction prevents oxidative damage induced by the carcinogen clofibrate in mouse liver. FEBS Letters 473 (1) : 85-88. ScholarBank@NUS Repository. https://doi.org/10.1016/S0014-5793(00)01506-4
Abstract: Long-term caloric restriction in rodents is known to decrease levels of oxidative damage, which may contribute to an 'anti-ageing' effect. We show here that a shorter period (10 months) of caloric restriction had only small effects on levels of oxidative DNA and protein damage in the livers of mice, but completely attenuated increased oxidative damage caused by the carcinogen clofibrate. Since clofibrate is thought to exert its actions by increasing oxidative damage, our data suggest that 10 months of caloric restriction can increase the resistance of tissues to agents inducing oxidative stress. This may be an important factor in explaining how caloric restriction decreases cancer incidence. Copyright (C) 2000 Federation of European Biochemical Societies.
Source Title: FEBS Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/32044
ISSN: 00145793
DOI: 10.1016/S0014-5793(00)01506-4
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