Clinicopathological study of biomarkers in prostrate cancer

Abstract

Prostate cancer is the third commonest malignancy among Singaporean men. The increase can be attributed to aging population, serum PSA screening and the application of TRUS. 170 cases of prostatic acinar adenocarcinoma of male patients who underwent radical prostatectomy were being studied. Clinicopathological and histological parameters were being evaluated against biomarkers - p53, Ki-67, androgen receptor, Her-2/neu, chromogranin A, CD56 and synaptophysin to determine if correlation can be established. Ki-67 and p53 have been found to be associated with adverse pathological variables. Ki-67 was positively correlated to PSA level as indicated by a p value of 0.041 while p53 intensity was positively correlated to Gleason score as indicated by p value of 0.018. Ki-67 and p53 were also observed to be positively correlated with AR. Ki-67 immunoreactive score (IRS) was positively correlated to AR IRS as indicated by p value of 0.055; p53 intensity-percentage score (IPS), p53 IRS were positively correlated to AR IPS and AR IRS as indicated by p value of 0.041 and 0.015 respectively.Correlations between Her-2/neu, neuroendocrine markers and clinicopathological parameters did not yield any significant statistical p values. Future studies may include enlaring the patient cohort and widening the panels of antibodies to be evaluated, in order to glean knowledge on the role of biological markers in prostate cancer.