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|Title:||Transplantation of neonatal porcine islets and Sertoli cells into nonimmunosuppressed nonhuman primates|
|Authors:||Isaac, J.R. |
|Citation:||Isaac, J.R., Khoo, A., Calne, R., Wang, D.Z., Lee, K.O., Salto-Tellez, M., Skinner, S., Elliot, R., Garkavenko, O. (2005). Transplantation of neonatal porcine islets and Sertoli cells into nonimmunosuppressed nonhuman primates. Transplantation Proceedings 37 (1) : 487-488. ScholarBank@NUS Repository. https://doi.org/10.1016/j.transproceed.2004.11.062|
|Abstract:||A Mexican group reported transplantation of cocultured neonatal porcine islets and Sertoli cells resulting in insulin independence in nonimmunosuppressed type 1 diabetes patients. We have transplanted similar islets alone (naked islets) or cocultured islets with sertoli cells (islet/sertoli cells) into an omental site and other locations of seven nondiabetic, nonimmunosuppressed, nonhuman primates. Porcine endogenous retrovirus was not detected in recipient blood 8 weeks after porcine islet grafts, and porcine C-peptide was detected at a very low level in all animals. Histology examination failed to demonstrate obviously recognizable islets, but in the animals transplanted with islet/Sertoli cells at the omentum site, there were some surviving glucagons, pan-cytokeratin, and inhibin stained cells at 8 weeks. © 2005 by Elsevier Inc. All rights reserved.|
|Source Title:||Transplantation Proceedings|
|Appears in Collections:||Staff Publications|
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