Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/29956
Title: Sex Differences in the Corpus Callosum in Schizophrenia: A Combined MRI and DTI Study
Authors: GAN SWU CHYI
Keywords: schizophrenia, MRI, DRI, chronic, first-episode, sex
Issue Date: 17-May-2011
Source: GAN SWU CHYI (2011-05-17). Sex Differences in the Corpus Callosum in Schizophrenia: A Combined MRI and DTI Study. ScholarBank@NUS Repository.
Abstract: Past research has identified abnormalities in the corpus callosum (CC), a structure that serves as the primary pathway for interhemispheric communication, in patients with schizophrenia, but the existence of sex differences in the CC remains contentious. This thesis is an investigation of CC size and microstructural abnormalities and the presence of sex differences in the structure in people with schizophrenia. Using Magnetic Resonance Imaging (MRI) techniques including volumetric and diffusion tensor methods, the area, volume and fractional anisotropy (FA) of the CC and its 5 constituent segments were measured in a large group of schizophrenia patients (N = 120), consisting of both first-episode and chronic cases, and a control group of age and sex matched healthy individuals (N = 75). Results indicated that the size (both area and volume) of the CC was significantly reduced in patients relative to controls, with chronic patients demonstrating the smallest volumes, followed by first-episode patients and healthy controls. There were no significant differences in CC size between the sexes, nor was the interaction between sex and diagnosis significant. At the same time, CC FAs did not differ significantly between the sexes or between schizophrenia patients and controls. The results suggest that the CC is neither sexually dimorphic in healthy individuals nor in schizophrenia patients. The neurodegenerative hypothesis of schizophrenia is supported as findings suggest that structural abnormalities worsen with illness progression.
URI: http://scholarbank.nus.edu.sg/handle/10635/29956
Appears in Collections:Master's Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Thesis final GSC.pdf531.74 kBAdobe PDF

OPEN

NoneView/Download

Page view(s)

253
checked on Dec 11, 2017

Download(s)

327
checked on Dec 11, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.