Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.biomaterials.2003.09.112
Title: Photo-crosslinkable microcapsules formed by polyelectrolyte copolymer and modified collagen for rat hepatocyte encapsulation
Authors: Quek, C.-H.
Li, J. 
Sun, T.
Gan, L.M.
Leong, K.W.
Yu, H. 
Chan, M.L.H.
Mao, H.-Q. 
Keywords: Cell-encapsulation
Collagen
Hepatocyte
Microcapsule
Photo-crosslinking
Polyelectrolyte
Issue Date: 2004
Source: Quek, C.-H., Li, J., Sun, T., Gan, L.M., Leong, K.W., Yu, H., Chan, M.L.H., Mao, H.-Q. (2004). Photo-crosslinkable microcapsules formed by polyelectrolyte copolymer and modified collagen for rat hepatocyte encapsulation. Biomaterials 25 (17) : 3531-3540. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biomaterials.2003.09.112
Abstract: New anionic polyelectrolyte tetra-copolymers with photo-crosslinkable 4-(4-methoxycinnamoyl)phenyl methacrylate monomer in addition to a HEMA-MMA-MAA ter-copolymer system were synthesized. The tetra-copolymers were used to form photo-crosslinkable microcapsules with modified collagen by complex coacervation for rat hepatocytes encapsulation. The hepatocytes were encapsulated within a two-layered membrane comprising of modified collagen as the inner core and an outer photo-crosslinkable copolymer shell. Upon photo-crosslinking of the microcapsules with UV-Vis light irradiation, the mechanical strength and chemical stability of the microcapsules, and the cellular functions of the encapsulated hepatocytes were enhanced. Particularly, the mechanical stability of the microcapsules was dramatically strengthened. The new photo-crosslinkable tetra-copolymer formulation described in this article has opened a way to the development of hepatocyte microencapsulation technology for bioartifical liver assist device. © 2003 Elsevier Ltd. All rights reserved.
Source Title: Biomaterials
URI: http://scholarbank.nus.edu.sg/handle/10635/29741
ISSN: 01429612
DOI: 10.1016/j.biomaterials.2003.09.112
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