Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bbrc.2006.11.038
Title: Promotion of atherogenesis by copper or iron-Which is more likely?
Authors: Rajendran, R.
Ren, M. 
Watt, F. 
Ning, P.
Halliwell, B. 
Tan, Kwong Huat B. 
Keywords: Copper
Elemental analysis
Iron
Nuclear microscopy
Issue Date: 2007
Source: Rajendran, R., Ren, M., Watt, F., Ning, P., Halliwell, B., Tan, Kwong Huat B. (2007). Promotion of atherogenesis by copper or iron-Which is more likely?. Biochemical and Biophysical Research Communications 353 (1) : 6-10. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bbrc.2006.11.038
Abstract: Iron levels increase in atherosclerotic lesions in cholesterol fed-rabbits and play a role in atherosclerosis. We investigated whether copper also rises. Male New Zealand White rabbits were fed high-cholesterol diets for 8 weeks. After sacrifice, lesion sizes were determined, and elemental analyses of the lesion and unaffected artery wall performed using nuclear microscopy. Unlike iron, lesion copper is decreased by about half compared with the unaffected artery wall, and much less copper than iron is present. Our data suggest that iron may be more likely to play a role in the promotion of atherosclerosis than copper. © 2006 Elsevier Inc. All rights reserved.
Source Title: Biochemical and Biophysical Research Communications
URI: http://scholarbank.nus.edu.sg/handle/10635/28897
ISSN: 0006291X
10902104
DOI: 10.1016/j.bbrc.2006.11.038
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