Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.mito.2006.07.006
Title: The role of the mitochondrial permeability transition in cell death
Authors: Armstrong, J.S. 
Keywords: Apoptosis
Bcl-2
Cyclosporine A
Mitochondria
Mitochondrial permeability transition
Necrosis
Reactive oxygen species
Issue Date: 2006
Source: Armstrong, J.S. (2006). The role of the mitochondrial permeability transition in cell death. Mitochondrion 6 (5) : 225-234. ScholarBank@NUS Repository. https://doi.org/10.1016/j.mito.2006.07.006
Abstract: The mitochondrial permeability transition (MPT) is a non-selective inner membrane permeabilization that occurs in response to increased calcium load and redox stress. Currently, two models of the MPT exist including the, largely hypothetical, native proteinaceous pore model and the oxidized inner membrane protein model which may reflect the extremes in a continuum of changes that occur to the inner membrane prior to its permeabilization. Here I discuss evidence that the MPT per se leads to necrosis, but not cytochrome c release and apoptosis. However, data also suggest that signaling crosstalk between the MPT and Bcl-2 family proteins occurs indicating an important role for the MPT in apoptosis. © 2006 Mitochondria Research Society.
Source Title: Mitochondrion
URI: http://scholarbank.nus.edu.sg/handle/10635/28779
ISSN: 15677249
DOI: 10.1016/j.mito.2006.07.006
Appears in Collections:Staff Publications

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