Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bbrc.2008.01.063
Title: Leptin as a neuroprotective agent
Authors: Tang, B.L. 
Keywords: JAK-STAT
Leptin
Neuroprotection
Neuroregeneration
Issue Date: 2008
Source: Tang, B.L. (2008). Leptin as a neuroprotective agent. Biochemical and Biophysical Research Communications 368 (2) : 181-185. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bbrc.2008.01.063
Abstract: Leptin is a hormone produced by adipocytes that regulates satiety (food uptake) and energy homeostasis by activating receptors expressed in neurons of the hypothalamus. Leptin receptors are also found in other brain regions such as the hippocampus and cerebral cortex, and have known roles in regulating neural development and neuroendocrine functions. Recent evidence indicates that leptin could be neuroprotective, enhancing neuronal survival both in vitro and in vivo. Intriguingly, administration of leptin protects against neuronal death in animal models of cerebral ischemic injury and hemiparkisonism. Activation of the Janus kinase (JAK)-signal transducers and activator of transcription (STAT), phosphatidylinositol (PI) 3-kinase and the extracellular signal regulated kinase (ERK) pathways are known downstream events of leptin receptor signaling, all of which are pro-survival and anti-apoptotic. The relative ease of leptin's accessibility to the brain by peripheral administration makes it a potential drug candidate in the development of therapeutics for brain injuries and neurodegeneration. © 2008 Elsevier Inc. All rights reserved.
Source Title: Biochemical and Biophysical Research Communications
URI: http://scholarbank.nus.edu.sg/handle/10635/28717
ISSN: 0006291X
10902104
DOI: 10.1016/j.bbrc.2008.01.063
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