Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bbrc.2006.06.153
Title: Modulation of peroxynitrite-induced fibroblast injury by hesperetin: A role for intracellular scavenging and modulation of ERK signalling
Authors: Pollard, S.E.
Spencer, J.P.E.
Whiteman, M. 
Keywords: ERK
Fibroblast
Flavonoid
Hesperetin
MAP kinase
Peroxynitrite
SIN-1
Issue Date: 2006
Source: Pollard, S.E., Spencer, J.P.E., Whiteman, M. (2006). Modulation of peroxynitrite-induced fibroblast injury by hesperetin: A role for intracellular scavenging and modulation of ERK signalling. Biochemical and Biophysical Research Communications 347 (4) : 916-923. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bbrc.2006.06.153
Abstract: Peroxynitrite is thought to contribute to the progression of many diseases including cardiovascular disease, cancer, and neurodegenerative disorders. We report that pre-treatment of fibroblasts with the citrus flavanone, hesperetin, prior to peroxynitrite exposure protects against peroxynitrite-mediated cytotoxicity. This protection was partially mediated by the intracellular scavenging of peroxynitrite by hesperetin as exposure of fibroblasts to peroxynitrite following hesperetin loading led to the formation of two intracellular nitro-hesperetin derivatives. In addition, protection appeared to be mediated by hesperetin-induced changes in MAP kinase signalling. Exposure of fibroblasts to hesperetin led to concentration-dependent increases in the phosphorylation of ERK1/2 and was observed to restore peroxynitrite-mediated decreases in ERK1/2 phosphorylation. We propose that the protective potential of hesperetin in fibroblasts may be mediated both by intracellular scavenging of peroxynitrite and by modulation of fibroblast signalling. © 2006 Elsevier Inc. All rights reserved.
Source Title: Biochemical and Biophysical Research Communications
URI: http://scholarbank.nus.edu.sg/handle/10635/28617
ISSN: 0006291X
10902104
DOI: 10.1016/j.bbrc.2006.06.153
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