Please use this identifier to cite or link to this item:
|Title:||Elevated F2-isoprostanes in thalassemic patients|
|Citation:||Matayatsuk, C., Wilairat, P., Lee, C.-Y.J., Halliwell, B., Kalpravidh, R.W., Sirankapracha, P., Fucharoen, S. (2007). Elevated F2-isoprostanes in thalassemic patients. Free Radical Biology and Medicine 43 (12) : 1649-1655. ScholarBank@NUS Repository. https://doi.org/10.1016/j.freeradbiomed.2007.08.026|
|Abstract:||This study was aimed at investigating oxidative stress in thalassemic patients by measurement of the oxidative damage biomarker, F2-isoprostanes (F2-IsoPs), using gas chromatography-mass spectrometry. The results showed that the mean value of urinary F2-IsoPs, normalized with creatinine, in the thalassemic group was significantly higher than that from healthy subjects (3.38 ± 2.15 ng/mg creatinine vs 0.86 ± 0.55 ng/mg creatinine, respectively), and the mean value of plasma total F2-IsoPs in the thalassemic group was also significantly higher than that from healthy subjects (0.39 ± 0.15 ng/ml vs 0.18 ± 0.03 ng/ml, respectively). Serum ferritin, erythrocyte superoxide dismutase (SOD), glutathione peroxidase, glutathione, and TBARS levels after treatment of erythrocytes with H2O2 were also investigated, and serum ferritin and erythrocyte SOD levels were significantly higher in thalassemic patients. Our findings are consistent with oxidative stress in thalassemia patients. © 2007 Elsevier Inc. All rights reserved.|
|Source Title:||Free Radical Biology and Medicine|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Feb 21, 2019
WEB OF SCIENCETM
checked on Feb 12, 2019
checked on Feb 3, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.