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Title: C. elegans BED domain transcription factor BED-3 controls lineage-specific cell proliferation during organogenesis
Authors: Inoue, T. 
Sternberg, P.W.
Keywords: BED domain
C. elegans
Cell cycle regulation
Cell division
Cell proliferation
Gene regulatory network (GRN)
Zinc finger
Issue Date: 2010
Source: Inoue, T., Sternberg, P.W. (2010). C. elegans BED domain transcription factor BED-3 controls lineage-specific cell proliferation during organogenesis. Developmental Biology 338 (2) : 226-236. ScholarBank@NUS Repository.
Abstract: The control of cell division is critical to organogenesis, but how this control is achieved is not fully understood. We found that mutations in bed-3, encoding a BED Zn-finger domain transcription factor, confer a phenotype where a specific set of cell divisions during vulval organogenesis is lost. Unlike general cell cycle regulators in Caenorhabditis elegans, the function of bed-3 is restricted to specific lineages. Transcriptional reporters suggest that bed-3 is expressed in a limited number of cell types including vulval cells whose divisions are affected in bed-3 mutants. A bed-3 mutation also affects the expression pattern of the cdh-3 cadherin gene in the vulva. The phenotype of bed-3 mutants is similar to the phenotype caused by mutations in cog-1 (Nkx6), a component of a gene regulatory network controlling cell type specific gene expression in the vulval lineage. These results suggest that bed-3 is a key component linking the gene regulatory network controlling cell-type specification to control of cell division during vulval organogenesis. © 2009 Elsevier Inc. All rights reserved.
Source Title: Developmental Biology
ISSN: 00121606
DOI: 10.1016/j.ydbio.2009.12.005
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