Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/28335
Title: A linkage disequilibrium map of the human major histocompatibility complex in Singapore Chinese: Conserved extended haplotypes and ancestral blocks
Authors: CHIA JER-MING
Keywords: MHC Chinese Linkage disequilibrium haplotypes HLA
Issue Date: 9-Jun-2009
Source: CHIA JER-MING (2009-06-09). A linkage disequilibrium map of the human major histocompatibility complex in Singapore Chinese: Conserved extended haplotypes and ancestral blocks. ScholarBank@NUS Repository.
Abstract: The linkage disequilibrium (LD) structure of the human major histocompatibility complex (MHC) in the Singaporean Chinese population is described using 3 SNP maps of increasing marker density. First, the LD of the chromosome 6p was analysed in 192 individuals. These samples were then genotyped at a higher resolution across an extended MHC segment to obtain a better granularity of LD. Finally a larger set of 252 individuals was genotyped at a high resolution with 2360 SNPs across the MHC. The inclusion of HLA-homozygous individuals enabled the detailed description of conserved extended haplotypes (CEH) that stretch across more than 2.5Mb, including the A33-B58-DR3 and A2-B46-DR9 CEHs that are present at high frequency in the population. Fixed ancestral blocks not shuffled by recombination are also seen shared between HLA haplotypes of a common lineage. The results presented here provide an essential resource for understanding LD and mapping disease associations in the MHC.
URI: http://scholarbank.nus.edu.sg/handle/10635/28335
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
0.Cover_Inserts.pdf183.79 kBAdobe PDF

OPEN

NoneView/Download
1.Introduction.pdf1.66 MBAdobe PDF

OPEN

NoneView/Download
2.Methods.pdf389.61 kBAdobe PDF

OPEN

NoneView/Download
3-1.results.pdf7.41 MBAdobe PDF

OPEN

NoneView/Download
3-2.results.pdf6.44 MBAdobe PDF

OPEN

NoneView/Download
3-3.results.pdf1.4 MBAdobe PDF

OPEN

NoneView/Download
3-4.results.pdf17.52 MBAdobe PDF

OPEN

NoneView/Download
3-5.results.pdf6.63 MBAdobe PDF

OPEN

NoneView/Download
4.Discussion.pdf152.2 kBAdobe PDF

OPEN

NoneView/Download
5.References_Appendix.pdf511.16 kBAdobe PDF

OPEN

NoneView/Download

Page view(s)

260
checked on Dec 11, 2017

Download(s)

1,458
checked on Dec 11, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.