Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.regpep.2005.02.007
Title: Effect of des-aspartate-angiotensin I on the actions of angiotensin II in the isolated renal and mesenteric vasculature of hypertensive and STZ-induced diabetic rats
Authors: Dharmani, M.
Mustafa, M.R.
Achike, F.I.
Sim, M.K. 
Keywords: Angiotensin II
Des-aspartate-angiotensin I
Mesenteric
Renal
Streptozotocin
Vasculature
Issue Date: 2005
Source: Dharmani, M., Mustafa, M.R., Achike, F.I., Sim, M.K. (2005). Effect of des-aspartate-angiotensin I on the actions of angiotensin II in the isolated renal and mesenteric vasculature of hypertensive and STZ-induced diabetic rats. Regulatory Peptides 129 (1-3) : 213-219. ScholarBank@NUS Repository. https://doi.org/10.1016/j.regpep.2005.02.007
Abstract: The present study investigated the action of des-aspartate-angiotensin I (DAA-I) on the pressor action of angiotensin II in the renal and mesenteric vasculature of WKY, SHR and streptozotocin (STZ)-induced diabetic rats. Angiotensin II-induced a dose-dependent pressor response in the renal vasculature. Compared to the WKY, the pressor response was enhanced in the SHR and reduced in the STZ-induced diabetic rat. DAA-I attenuated the angiotensin II pressor action in renal vasculature of WKY and SHR. The attenuation was observed for DAA-I concentration as low as 10-18 M and was more prominent in SHR. However, the ability of DAA-I to reduce angiotensin II response was lost in the STZ-induced diabetic kidney. Instead, enhancement of angiotensin II pressor response was seen at the lower doses of the octapeptide. The effect of DAA-I was not inhibited by PD123319, an AT2 receptor antagonist, and indomethacin, a cyclo-oxygenase inhibitor in both WKY and SHR, indicating that its action was not mediated by angiotensin AT2 receptor and prostaglandins. The pressor responses to angiotensin II in mesenteric vascular bed were also dose-dependent but smaller in magnitude compared to the renal vasculature. The responses were significantly smaller in SHR but no significant difference was observed between STZ-induced diabetic and WKY rat. Similarly, PD123319 and indomethacin had no effect on the action of DAA-I. The findings reiterate a regulatory role for DAA-I in vascular bed of the kidney and mesentery. By being active at circulating level, DAA-I subserves a physiological role. This function appears to be present in animals with diseased state of hypertension and diabetes. It is likely that DAA-I functions are modified to accommodate the ongoing vascular remodeling. © 2005 Elsevier B.V. All rights reserved.
Source Title: Regulatory Peptides
URI: http://scholarbank.nus.edu.sg/handle/10635/27281
ISSN: 01670115
DOI: 10.1016/j.regpep.2005.02.007
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

10
checked on Dec 6, 2017

WEB OF SCIENCETM
Citations

9
checked on Nov 21, 2017

Page view(s)

124
checked on Dec 10, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.