Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ijcard.2010.02.017
Title: Comparison between fixed-dose, intracoronary bolus-only versus standard weight-adjusted dose, intravenous bolus and infusion administration of abciximab in patients undergoing primary percutaneous coronary intervention
Authors: Lee, C.-H. 
Ngo, H.M.
Sewianto, A.
Nguyen, T.H.
Lee, J.
Teo, S.-G.
Low, A.F. 
Tan, H.-C. 
Keywords: Abciximab
Bolus
ST-segment elevation myocardial infarction
Issue Date: 2010
Source: Lee, C.-H., Ngo, H.M., Sewianto, A., Nguyen, T.H., Lee, J., Teo, S.-G., Low, A.F., Tan, H.-C. (2010). Comparison between fixed-dose, intracoronary bolus-only versus standard weight-adjusted dose, intravenous bolus and infusion administration of abciximab in patients undergoing primary percutaneous coronary intervention. International Journal of Cardiology 145 (2) : 355-357. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ijcard.2010.02.017
Abstract: We studied the safety and effectiveness of fixed-dose, intracoronary bolus-only abciximab in 195 patients who underwent primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. The patients were divided into 2 groups: Group A (n = 120, 61.5%) received fixed-dose, intracoronary bolus-only, abciximab 10 mg; and Group B (n = 75, 38.5%) received standard intravenous bolus (0.25 mg/kg) and maintenance abciximab infusion of 0.125 μg/kg/min for 12 h. There was no statistically significant difference in the baseline and post-procedure TIMI flow between Groups A and B. Final TIMI 3 flow was achieved in 90.0% and 89.3% of the patients in Groups A and B, respectively (p = 0.14). Final TIMI myocardial perfusion grade 2/3 was achieved in 92.5% and 96.0% of the patients in Groups A and B, respectively (p = 0.45). The six-month clinical outcomes were similar between Groups A and B (8.3% versus 5.3%, p = 0.62). © 2010 Elsevier Ireland Ltd. All rights reserved.
Source Title: International Journal of Cardiology
URI: http://scholarbank.nus.edu.sg/handle/10635/26916
ISSN: 01675273
DOI: 10.1016/j.ijcard.2010.02.017
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