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|Title:||The Mitral Annular Middiastolic Velocity Curve: Functional Correlates and Clinical Significance in Patients with Left Ventricular Hypertrophy|
|Authors:||Lam, C.S.P. |
|Citation:||Lam, C.S.P., Han, L., Yang, H., Ling, L.H., Oh, J.K. (2008). The Mitral Annular Middiastolic Velocity Curve: Functional Correlates and Clinical Significance in Patients with Left Ventricular Hypertrophy. Journal of the American Society of Echocardiography 21 (2) : 165-170. ScholarBank@NUS Repository. https://doi.org/10.1016/j.echo.2007.05.027|
|Abstract:||Background: Little is known regarding the tissue Doppler characteristics and clinical significance of mitral annular motion during diastasis (L' wave). Methods: In consecutive patients with left ventricular hypertrophy and normal ejection fraction, standard Doppler and Doppler tissue imaging were performed. Patients were followed up for heart failure (HF) hospitalization. Results: Of 177 patients, 53 (30%) had an L′, detected most frequently at the lateral mitral annulus, whereas 35 (20%) had middiastolic transmitral flow (L wave), which almost invariably coexisted with the L'. The L' predicted increased left ventricular filling pressure with 74% sensitivity and 82% specificity, and increased risk of future HF (hazard ratio 3.9 [P = .030]), even after adjusting for baseline clinical differences (hazard ratio 6.5 [P = .024]). When associated with an L wave, HF risk increased further. Conclusions: Middiastolic annular motion, detectable in almost a third of patients with left ventricular hypertrophy, may be an early marker of diastolic dysfunction and a prognostic marker for HF. © 2008 American Society of Echocardiography.|
|Source Title:||Journal of the American Society of Echocardiography|
|Appears in Collections:||Staff Publications|
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